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. 2015 Sep;15(9):1296-303.
doi: 10.1002/mabi.201500078. Epub 2015 May 28.

The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato  1 , Shingo Kobayashi  1   2 , Miho Kusakari  1 , Shogo Watahiki  1 , Masahiko Oikawa  1 , Takashi Hoshiba  1   3 , Masaru Tanaka  4   5
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The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato et al. Macromol Biosci. 2015 Sep.

Abstract

Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

Keywords: biomaterial; blood compatibility; intermediate water; protein adsorption; water structure.

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