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. 2015 May 27;13(5):e1002156.
doi: 10.1371/journal.pbio.1002156. eCollection 2015 May.

Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

Natalie Burden  1 , Fiona Sewell  1 , Kathryn Chapman  1
Affiliations

Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

Natalie Burden et al. PLoS Biol. .

Abstract

Scientists face growing pressure to move away from using traditional animal toxicity tests to determine whether manufactured chemicals are safe. Numerous ethical, scientific, business, and legislative incentives will help to drive this shift. However, a number of hurdles must be overcome in the coming years before non-animal methods are adopted into widespread practice, particularly from regulatory, scientific, and global perspectives. Several initiatives are nevertheless underway that promise to increase the confidence in newer alternative methods, which will support the move towards a future in which less data from animal tests is required in the assessment of chemical safety.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Russell WMS, Burch RL (1959) The Principles of Humane Experimental Technique. London: Methuen.
    1. EC (2009) Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on Cosmetic Products. OJ L 342: Official Journal of the European Union.
    1. EC (2006) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. OJ L 396. Official Journal of the European Union.
    1. Rovida C, Hartung T (2009) Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals—a report by the transatlantic think tank for toxicology (t(4)). Altex 26: 187–208. - PubMed
    1. Holmes AM, Solari R, Holgate ST (2011) Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug discovery today 16: 659–670. 10.1016/j.drudis.2011.05.014 - DOI - PubMed

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