Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;6(2):231-2.
doi: 10.1093/ckj/sft023.

Peculiarly progressive tetraplegia

Saban Elitok  1 , Wolfgang Schneider  2 , Friedrich C Luft  2 , M G Zeier  1
Affiliations

Peculiarly progressive tetraplegia

Saban Elitok et al. Clin Kidney J. 2013 Apr.
No abstract available

Keywords: K+/H+ ATPase pump; autoimmunity; carbonic anhydrase; hypokalaemia; metabolic acidosis; respiratory acidosis.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Haematoxylin and eosin stain of renal biopsy documenting intense interstitial nephritis.
Fig. 2.
Fig. 2.
Schematic model of H+ secretion in the cortical collecting tubule. The main pump for luminal H+ secretion in the alpha type-intercalated cell is a vacuolar H+-ATPase. A H+,K+-ATPase is also involved in H+ secretion. Intracellularly formed HCO3− leaves the cell via Cl–HCO3− exchange, facilitated by an anion exchanger (AE1). Cytoplasmic carbonic anhydrase II (CA II) is necessary to secrete H+ (adapted) [2]. CA: Carbonic anhydrase, AE: anion exchanger.
See this image and copyright information in PMC

References

    1. Rhee EP, Scott JA, Dighe AS. A 37-year-old man with muscle pain, weakness, and weight loss. N Engl J Med. 2012;366:553–560. - PubMed
    1. Batlle D, Moorthi KM, Schlueter W, et al. Distal renal tubular acidosis and the potassium enigma. Semin Nephrol. 2006;26:471–478. - PubMed
    1. Pertovaara M, Bootorabi F, Kuuslahti M, et al. Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren's syndrome. Rheumatology. 2011;50:1453–1457. - PubMed
    1. Rehman HU. A woman with generalised weakness, hypokalaemia, and metabolic acidosis. BMJ. 2012;344:e2545. - PubMed

LinkOut - more resources