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. 2015 Mar;4(2):96-105.
doi: 10.1159/000367732.

Consensus Development from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014)

Chiun Hsu  1 , Bang-Bin Chen  2 , Chien-Hung Chen  3 , Ming-Chih Ho  4 , Jason Chia-Hsien Cheng  1 , Norihiro Kokudo  5 , Takamichi Murakami  6 , Winnie Yeo  7 , Jinsil Seong  8 , Ji-Dong Jia  9 , Kwan-Hyub Han  10 , Ann-Lii Cheng  11
Affiliations

Consensus Development from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014)

Chiun Hsu et al. Liver Cancer. 2015 Mar.

Abstract

A key mission of the Asia-Pacific Primary Liver Cancer Expert (APPLE) Association is to ensure a coherent view for management of hepatocellular carcinoma (HCC) and to advance new treatment for this difficult disease. At the 5th APPLE meeting, held in July 2014 in Taipei, Taiwan, an APPLE consensus development program was established to facilitate discussion among experts in the Asia-Pacific region on pertinent issues for HCC management, including (1) surgery for intermediate/advanced-stage disease, (2) prevention of HCC recurrence after curative treatment, (3) optimizing imaging diagnosis, (4) radiotherapy: current practice and future clinical trials, and (5) the role of cytotoxic chemotherapy. A pre-congress questionnaire was undertaken with the consensus development committee members to help understand the current practice patterns for HCC in the Asia-Pacific region and to identify issues relating to optimal patient care and further clinical trials for which consensus needs to be developed. In this report, the results of the questionnaire are presented, and the pertinent issues identified by each consensus group for further discussion and consensus development are summarized.

Keywords: Chemotherapy; Hepatocellular carcinoma; Imaging; Radiotherapy; Surgery.

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Figures

Fig. 1
Fig. 1
a Approximate numbers of newly diagnosed HCC patients each year. b Approximate numbers of HCC patients referred to the respondents' institution each year. c Percentage of patients with a histological diagnosis. d Proportion of the underlying etiologies.
Fig. 2
Fig. 2
Patterns of curative treatment. a Proportion of patients treated with curative intent who received surgery or ablation therapy in the respondents' institutions. RFA, radiofrequency ablation; PEIT; percutaneous ethanol injection therapy. b Annual patient volume of transplantation for HCC treatment (21 institutions). c Approximate proportion of HCC patients who have BCLC intermediate/advanced-stage disease and receive surgery with curative intent.
See this image and copyright information in PMC

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