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Review
. 2015 Nov;396(11):1163-79.
doi: 10.1515/hsz-2015-0141.

Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis

Marina Le Lamer, Laurence Pellerin, Marie Reynier, Laura Cau, Valérie Pendaries, Corinne Leprince, Marie-Claire Méchin, Guy Serre, Carle Paul, Michel Simon
Review

Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis

Marina Le Lamer et al. Biol Chem. 2015 Nov.

Erratum in

Abstract

The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2-3% of adults and often precedes the development of allergic rhinitis and asthma. This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components. The consequences of the epidermal barrier alteration on our current understanding of the pathogenesis of AD, and its possible implications on the treatment of patients, are discussed here.

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