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Case Reports
. 2015 Apr;9(4):BD01-2.
doi: 10.7860/JCDR/2015/11515.5799. Epub 2015 Apr 1.

Bronze diabetes

Akshatha L N  1 , Mamatha T Shenoy  1 , Charu Yadav  1 , Rukmini M S  2 , Nutan Kamath  3
Affiliations
Case Reports

Bronze diabetes

Akshatha L N et al. J Clin Diagn Res. 2015 Apr.

Abstract

Thalassemia is a group of disorders characterized by deficient production of the β-globin sub unit of hemoglobin. The mandatory blood transfusions in patients with thalassemia to maintain adequate erythrocyte levels, leads to iron overload. The prevalence of diabetes in patients with thalassemia varies from 6 to 14%. We here by present a known case of thalassemia major in an 18 year old boy. He was diagnosed with thalassemia before the age of one year and is on regular blood transfusion every two weeks since then. The repeated blood transfusion is one of the common causes for haemochromatosis. Iron overload initially leads to glucose abnormalities such as insulin resistance and hyperinsulinemia, which is followed by impaired secretion of insulin. Diagnosed as a case of bronze diabetes, this patient is on insulin therapy for the last two years. Currently the patient is on iron chelation therapy at Kasturba Medical College Hospital, Mangalore, Karnataka, India.

Keywords: Serum ferritin; Thalassemia; Type I diabetes.

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References

    1. A Eghbali, H Taherahmadi, M Shahbazi, B Bagheri, L Ebrahimi. Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia. Iran J Ped Hematol Oncol. 2014;4(1):17–21. - PMC - PubMed
    1. J Montonen, h Boeing, A Steffen, R Lehmann, A Fritsche, HC Joost. Body iron stores and risk of type 2 diabetes: results from the european prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetologia. 2012;55(10):2613–21. - PMC - PubMed
    1. I Shahramian, M Razzaghian, AA Ramazani, GA Ahmadi, NM Noori, AR Rezaee. The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia. Int Cardiovasc Res J. 2013;7(2):51–55. - PMC - PubMed
    1. MP Veríssimo, SR Loggetto, A Fabron Junior, GR Baldanzi, N Hamerschlak, JL Fernandes, et al. Brazilian Thalassemia Association protocol for iron chelation therapy in patients under regular transfusion. Rev Bras Hematol Hemoter. 2013;35(6):428–34. - PMC - PubMed
    1. N Gattermann. The treatment of secondary hemochromatosis. Dtsch Arztebl Int. 2009;106(30):499–504. - PMC - PubMed

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