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. 1989 Dec;86(24):10104-7.
doi: 10.1073/pnas.86.24.10104.

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation

D E Hallahan  1 , D R Spriggs, M A Beckett, D W Kufe, R R Weichselbaum
Affiliations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation

D E Hallahan et al. Proc Natl Acad Sci U S A. 1989 Dec.

Abstract

We report that tumor necrosis factor alpha (TNF-alpha) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-alpha mRNA is accompanied by the increased production of TNF-alpha protein. TNF-alpha enhances radiation lethality in both TNF-alpha-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-alpha may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-alpha and therapeutic radiation may be useful in clinical cancer therapy.

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References

    1. Int J Radiat Oncol Biol Phys. 1988 Oct;15(4):937-42 - PubMed
    1. Mol Cell Biol. 1989 Feb;9(2):851-3 - PubMed
    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Mar;29(3):293-6 - PubMed
    1. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1165-74 - PubMed
    1. Cancer Res. 1980 Mar;40(3):920-5 - PubMed

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