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. 2015 May 27;13(6):3360-7.
doi: 10.3390/md13063360.

Myrothecols g and h, two new analogues of the marine-derived quinone sesquiterpene penicilliumin A

Ying Fu  1   2   3 , Ping Wu  4   5 , Jinghua Xue  6   7 , Hanxiang Li  8   9 , Xiaoyi Wei  10   11
Affiliations

Myrothecols g and h, two new analogues of the marine-derived quinone sesquiterpene penicilliumin A

Ying Fu et al. Mar Drugs. .

Abstract

Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1' diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spectroscopic data combining with the theoretical conformational analysis. The cytotoxic activities of 1 and 2 were tested against a panel of human tumor cell lines.

Keywords: 13-hydroxyl penicilliumin A; cytotoxicity; myrothecol G; myrothecol H; quinone sesquiterpenes; stereochemistry; theoretical conformational analysis.

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Figures

Figure 1
Figure 1
Penicilliumin A and two analogues (1 and 2) from Myrothecium sp. SC0265.
Figure 2
Figure 2
1H–1H COSY (bold lines) and key HMBC correlations (arrows) of 1 and 2.
Figure 3
Figure 3
Dominant low-energy conformers (1a1, 1b1 and 2a1) and key NOE correlations (curves) of 1 and 2.
See this image and copyright information in PMC

References

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