Size doesn't matter; in the stroma, little things make all the difference
- PMID: 26024024
- DOI: 10.1038/ki.2015.77
Size doesn't matter; in the stroma, little things make all the difference
Abstract
In recent years there has been an increase in the number of studies into the role of stromal cells and microRNAs (miRNAs) in kidney development. Nakagawa et al. combine the two in a study of a stromal cell-specific knockout of Dicer1. The work identifies many important roles for miRNAs in these cells and kidney development in general, partially through their modification of the β-catenin signaling cascade.
Comment on
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Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis.Kidney Int. 2015 Jun;87(6):1125-40. doi: 10.1038/ki.2014.406. Epub 2015 Feb 4. Kidney Int. 2015. PMID: 25651362 Free PMC article.
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