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Meta-Analysis
. 2015 May 29;10(5):e0125655.
doi: 10.1371/journal.pone.0125655. eCollection 2015.

The prognosis of breast cancer patients after mastectomy and immediate breast reconstruction: a meta-analysis

Xue Yang  1 , Chenfang Zhu  1 , Yan Gu  1
Affiliations
Meta-Analysis

The prognosis of breast cancer patients after mastectomy and immediate breast reconstruction: a meta-analysis

Xue Yang et al. PLoS One. .

Abstract

Background: An increasing number of patients with breast cancer are being offered immediate breast reconstruction (IBR). The aim of this study was to analyze the impact of IBR on the prognosis of patients with breast cancer.

Methods: We searched the electronic databases of Medline (Pubmed), ISI Web of Knowledge, Embase, and Google Scholar databases for studies reporting the overall recurrence, disease-free survival (DFS), and overall survival (OS) of patients after mastectomy only and mastectomy with IBR. With these data, we conducted a meta-analysis of the clinical outcomes.

Results: Fourteen studies, including 3641 cases and 9462 controls, matched our criteria. Relevant information was extracted from these 14 studies. There was no significant heterogeneity (P for Q-statistic > 0.10 and I2 < 25%). Patients who underwent IBR showed no increased risk of overall recurrence of breast cancer (RR = 0.89; 95% confidence interval [CI]: 0.75, 1.04; P = 0.14). Furthermore, patients receiving IBR had similar DFS (RR = 1.04; 95%CI: 0.99, 1.08); P = 0.10) and OS (RR = 1.02; 95%CI: 0.99, 1.05; P = 0.24)) as those of control patients.

Conclusion: This meta-analysis provides evidence that IBR does not have an adverse effect on prognosis. These data suggest that IBR is an appropriate and safe choice for patients with breast cancer.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A flow diagram of the search process.
Fig 2
Fig 2. A funnel plot of the 14 included studies.
Fig 3
Fig 3. A Forest plot of the pooled RR of recurrence for the IBR and Control groups.
Fig 4
Fig 4. A Forest plot of the pooled RR of DFS for the IBR and Control groups.
Fig 5
Fig 5. A Forest plot of the pooled RR of OS for the IBR and Control group
See this image and copyright information in PMC

References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics[J]. CA: a cancer journal for clinicians. 2011; 61(2): 69–90. - PubMed
    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014[J]. CA: a cancer journal for clinicians. 2014; 64(1): 9–29. - PubMed
    1. Kim MK, Kim T, Moon HG, Jin US, Kim K, Kim J, et al. Effect of cosmetic outcome on quality of life after breast cancer surgery[J]. European Journal of Surgical Oncology (EJSO). 2014. - PubMed
    1. Joslyn SA. Patterns of care for immediate and early delayed breast reconstruction following mastectomy[J]. Plastic and reconstructive surgery. 2005;115(5): 1289–1296. - PubMed
    1. Göktaş SB, Güllüoğlu BM, Şelimen D. Immediate or Delayed Breast Reconstruction After Radical Mastectomy in Breast Cancer Patients:Does It Make a Difference in the Quality of Life[J]. Turkiye Klinikleri Journal of Medical Sciences. 2011; 31(3): 664.

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