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. 2015 Oct;136(4):1116-8.e9.
doi: 10.1016/j.jaci.2015.04.025. Epub 2015 May 27.

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

Marialbert Acosta-Herrera  1 , Maria Pino-Yanes  2 , Shwu-Fan Ma  3 , Amalia Barreto-Luis  4 , Almudena Corrales  4 , José Cumplido  5 , Eva Pérez-Rodríguez  6 , Paloma Campo  7 , Celeste Eng  8 , José Carlos García-Robaina  6 , Inés Quintela  9 , Jesús Villar  10 , Miguel Blanca  7 , Ángel Carracedo  11 , Teresa Carrillo  5 , Joe G N Garcia  12 , Dara G Torgerson  8 , Esteban G Burchard  13 , Carlos Flores  14
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Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

Marialbert Acosta-Herrera et al. J Allergy Clin Immunol. 2015 Oct.
No abstract available

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Figures

Figure 1
Figure 1. Regional plots of association results in the discovery sample (upper panel), GABRIEL (middle panel), and EVE (lower panel)
The -log10 transformed p-values for association tests are plotted as symbols according to their functional annotation. The SNP rs number indicated on the plot denotes the result for the most significantly associated SNP with asthma risk. The results for the remaining SNPs are color coded to reflect their degree of linkage disequilibrium with the most significant SNP based on pairwise r2 values from the European population of the 1KGP. Estimated recombination rates (light blue line) are plotted on the right y-axis.
See this image and copyright information in PMC

References

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