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. 2014 Mar 15:12:13-5.
doi: 10.1016/j.rmcr.2013.12.007. eCollection 2014.

Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae

Masafumi Seki  1 , Hisao Yoshida  1 , Kazuyoshi Gotoh  2 , Nobuyuki Hamada  3 , Daisuke Motooka  2 , Shota Nakamura  2 , Norihisa Yamamoto  1 , Shigeto Hamaguchi  1 , Yukihiro Akeda  4 , Hiroshi Watanabe  3 , Tetsuya Iida  2 , Kazunori Tomono  1
Affiliations

Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae

Masafumi Seki et al. Respir Med Case Rep. .

Abstract

A 64-year-old male patient was admitted with respiratory failure, although chest X-rays revealed only mild bronchiolitis. Streptococcus pneumoniae, which usually presents as massive lobular pneumonia, was isolated from sputum, however, pan-pathogen screening using a next-generation sequencer also detected human metapneumovirus genome fragments.

Keywords: Co-infection; Human metapneumovirus; Next-generation sequencer; Real-time PCR; Streptococcus pneumoniae.

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Figures

Fig. 1
Fig. 1
Chest radiography (A) and computed tomography (B) images upon admission. Absence of consolidation and small multiple lobular shadows in upper and middle fields of right lung suggests bronchiolitis.
Fig. 2
Fig. 2
Genetic analysis of hMPV in sputum. Alignment of complete HMPV genome sequence by nucleotide sequence using BLASTN. Reading obtained with MiSeq sequencer (query) was compared with that of HMPV strain Sabana (Subject: NCBI accession number, HM197719.1).
See this image and copyright information in PMC

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