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Editorial
. 2015;14(14):2185-6.
doi: 10.1080/15384101.2015.1056698. Epub 2015 Jun 1.

Lipids beyond membranes; farnesylation targets Spindly to kinetochores

Devinderjit Kaur Moudgil  1 , Gordon K T Chan
Affiliations
Editorial

Lipids beyond membranes; farnesylation targets Spindly to kinetochores

Devinderjit Kaur Moudgil et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
Farneyslation regulates kinetochore recruitment of Spindly. The RZZ complex is required for the kinetochore recruitment of dynein/dynactin (through Spindly) as well as Mad1-Mad2 (unknown mechanism dotted line). Farnesylation inhibition prevents RZZ/Spindly interaction and Spindly dependent dynein/dynactin localization leading to prometaphase delay and dynein independent checkpoint silencing. No silencing occurs when Spindly box point mutants localize but do not recruit dynein/dynactin.
See this image and copyright information in PMC

References

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