[Polyneuropathy of thin fibers]

Abstract

Polyneuropathy of thin fibers (PTF) is a disorder with selective damage of Aδ- and C-fibers. Having a skin biopsy the SFN became visible. In the article there are data on the pathogenesis, clinics and diagnostics of the PTF. The skin biopsy, the quantitative sensory testing, the corneal confocal microscopy, nociceptive evoked potentials, the microneurography and the autonomic testing are described in detail. New diagnostic criteria ofthe PTF are given. Main directions in the management of the PTF are the treatment of systemic diseases and the neuropathic pain relief.