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Review
. 2015 Jul;17(7):610.
doi: 10.1007/s11886-015-0610-z.

LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics?

Bernd Hewing  1 , Ulf Landmesser
Affiliations
Review

LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics?

Bernd Hewing et al. Curr Cardiol Rep. 2015 Jul.

Abstract

Over the past years, genetic studies on lipid traits have substantially extended our understanding of the relationship between lipid metabolism and coronary artery disease (CAD). Thereby, novel pathways and interactions in lipid metabolism unraveled by genetic studies have led to promising novel treatment strategies that are currently evaluated for prevention and treatment of CAD, such as low-density lipoprotein cholesterol (LDL-C) lowering by inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9). This review article discusses findings from recent genetic studies and their implications for the understanding of the relation between lipid metabolism and CAD as well as the development of novel therapeutic strategies supported by these studies.

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