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Review
. 2015 Jul;25(7):767-8.
doi: 10.1038/cr.2015.64. Epub 2015 Jun 2.

Targeted genome editing in primate embryos

Xiangyu Guo  1 , Xiao-Jiang Li  2
Affiliations
Review

Targeted genome editing in primate embryos

Xiangyu Guo et al. Cell Res. 2015 Jul.

Abstract

Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases.

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