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Comment
. 2015 Aug;25(8):891-2.
doi: 10.1038/cr.2015.65. Epub 2015 Jun 2.

A frightening thought: Neuronal activity enhances tumor growth

Emily G Thompson  1 , Harald Sontheimer  1
Affiliations
Comment

A frightening thought: Neuronal activity enhances tumor growth

Emily G Thompson et al. Cell Res. 2015 Aug.

Abstract

Stem cells present in the adult brain are regulated by neuronal activity; malignant gliomas, which most likely originate from this population of cells, could also be regulated in this manner. A recent study by Venkatesh et al. published in Cell has identified Neuroligin-3 (NLGN3) as a mitogen promoting high-grade glioma growth.

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Comment on

  • Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
    Venkatesh HS, Johung TB, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Polepalli J, Mitra SS, Woo PJ, Malenka RC, Vogel H, Bredel M, Mallick P, Monje M. Venkatesh HS, et al. Cell. 2015 May 7;161(4):803-16. doi: 10.1016/j.cell.2015.04.012. Epub 2015 Apr 23. Cell. 2015. PMID: 25913192 Free PMC article.

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