Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep;17(9):675-81.
doi: 10.1111/jch.12581. Epub 2015 Jun 1.

Obstructive Sleep Apnea Using Watch-PAT 200 Is Independently Associated With an Increase in Morning Blood Pressure Surge in Never-Treated Hypertensive Patients

Jung Sun Cho  1 , Sang-Hyun Ihm  1 , Chan Joon Kim  1 , Mahn-Won Park  1 , Sung-Ho Her  1 , Gyung-Min Park  1 , Tae-Seok Kim  1
Affiliations

Obstructive Sleep Apnea Using Watch-PAT 200 Is Independently Associated With an Increase in Morning Blood Pressure Surge in Never-Treated Hypertensive Patients

Jung Sun Cho et al. J Clin Hypertens (Greenwich). 2015 Sep.

Abstract

This study aimed to examine the association between obstructive sleep apnea (OSA) and morning blood pressure surge in never-treated patients with essential hypertension. This prospective study included a total of 58 patients (mean age, 51.7 years; 55.2% men) with never-treated essential hypertension. The patients were divided into non-OSA (n=23, 49.3±12.7 years) and OSA (n=35, 53.2±9.8 years) groups. The OSA group was defined as having an apnea-hypopnea index level >5 as measured by the Watch-PAT 200. The authors collected 24-hour ambulatory BP, plasma aldosterone concentration, and plasma renin activity data from all of the patients. The measured sleep-trough morning systolic blood pressure (SBP) increases were higher in the OSA group than in the non-OSA group (28.7±11.8 mm Hg vs 19.6±12.8 mm Hg, P=.008). The sleep-trough morning SBP increase was inversely correlated with the lowest oxygen saturation (r=-0.272, P=.039). OSA known to be associated with increased daytime and nocturnal sympathetic activity was associated with significantly higher sleep-trough morning SBP levels in this study.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Decreased peripheral arterial tonometry (PAT) amplitude was not frequent in nonobstructive sleep apnea (OSA) patients, and simultaneous ambulatory blood pressure monitoring (ABPM) revealed lower values of morning systolic blood pressure (SBP) and sleep‐trough morning SBP increases in non‐OSA patients compared with OSA patients (A). The frequently decreased PAT amplitude coupled with desaturation is shown (red box), and ABPM showed elevated morning SBP and sleep‐trough morning SBP increases in OSA patients (B).
Figure 2
Figure 2
The sleep‐trough morning systolic blood pressure (SBP) increase was inversely correlated with the lowest oxygen (O2) saturation. The apnea‐hypopnea index was significantly correlated with morning SBP and diastolic blood pressure.
See this image and copyright information in PMC

Comment in

References

    1. Okada H, Iwase S, Mano T, et al. Changes in muscle sympathetic nerve activity during sleep in humans. Neurology. 1991;41:1961–1966. - PubMed
    1. Bar A, Pillar G, Dvir I, et al. Evaluation of a portable device based on peripheral arterial tone for unattended home sleep studies. Chest. 2003;123:695–703. - PubMed
    1. Parish JM. Metabolic syndrome, obstructive sleep apnea, and risk of cardiovascular disease. Sleep Breath. 2012;16:595–597. - PubMed
    1. Shimizu M, Ishikawa J, Eguchi K, et al. Association of an abnormal blood glucose level and morning blood pressure surge in elderly subjects with hypertension. Am J Hypertens. 2009;22:611–616. - PubMed
    1. Trinder J, Kleiman J, Carrington M, et al. Autonomic activity during human sleep as a function of time and sleep stage. J Sleep Res. 2001;10:253–264. - PubMed

Publication types

MeSH terms