Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2015 Jun 1;5(6):e007390.
doi: 10.1136/bmjopen-2014-007390.

Women's perception of risks of adverse fetal pregnancy outcomes: a large-scale multinational survey

Affiliations
Multicenter Study

Women's perception of risks of adverse fetal pregnancy outcomes: a large-scale multinational survey

Irene Petersen et al. BMJ Open. .

Abstract

Objective: To determine pregnant women and new mothers' perception of risks in pregnancy.

Design, settings and participants: This was a large-scale multinational survey including 9113 pregnant women and new mothers from 18 countries in Europe, North America and Australia.

Main outcomes: Risk perception scores (0-10) for harmful effects to the fetus were derived for: (1) medicines (over-the-counter medicine and prescribed medicine), (2) food substances (eggs and blue veined cheese), (3) herbal substances (ginger and cranberries) (4) alcohol and tobacco, and (5) thalidomide.

Results: Overall, 80% (6453/8131) of women perceived the risk of giving birth to a child with a birth defect to be ≤ 5 of 100 births. The women rated cranberries and ginger least harmful (mean risk perception scores 1.1 and 1.5 of 10, respectively) and antidepressants, alcohol, smoking and thalidomide as most harmful (7.6, 8.6, 9.2 and 9.4 out of 10, respectively). The perception varied with age, level of education, pregnancy status, profession and geographical region. Noticeably, 70% had not heard about thalidomide, but of those who had (2692/9113), the risk perception scores were 0.4-0.5 points lower in women below 25 years compared to women aged 26-30 years.

Conclusions: In general, women perceived the risks of giving birth to a child with birth defects low, but there were substantial disparities between women's perceived risks and the actual risks when it comes to over-the-counter agents against nausea and prescribed medication. The study revealed that few women knew of thalidomide, suggesting that the general awareness among women of the teratogenic effects of thalidomide is declining, but it has left a general scepticism about safety of medication in pregnancy. This may have some severe consequences if women are left without medical treatments in pregnancy.

Keywords: perception of risks; pregnancy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean risk perception scores for 13 individual items by geographical region.

References

    1. McBride W. Thalidomide and congenital abnormalities. Lancet 1961;2:1358 10.1016/S0140-6736(61)90927-8 - DOI
    1. Petersen I, Gilbert RE, Evans SJW et al. Pregnancy as a major determinant for discontinuation of antidepressants: an analysis of data from The Health Improvement Network. J Clin Psychiatry 2011;72:979–85. 10.4088/JCP.10m06090blu - DOI - PubMed
    1. Man SL, Petersen I, Thompson M et al. Antiepileptic drugs during pregnancy in primary care: a UK population based study. PLoS ONE 2012;7:e52339 10.1371/journal.pone.0052339 - DOI - PMC - PubMed
    1. Nordeng H, Ystrom E, Einarson A. Perception of risk regarding the use of medications and other exposures during pregnancy. Eur J Clin Pharmacol 2010;66:207–14. 10.1007/s00228-009-0744-2 - DOI - PubMed
    1. Lupattelli A, Spigset O, Nordeng H. Adherence to medication for chronic disorders during pregnancy: results from a multinational study. Int J Clin Pharm 2014;36:145–53. 10.1007/s11096-013-9864-y - DOI - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources