Instructive Conductive 3D Silk Foam-Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation

John G Hardy^{1

2

3}, Sydney A Geissler^{4

5}, David Aguilar Jr⁵, Maria K Villancio-Wolter⁴, David J Mouser⁵, Rushi C Sukhavasi⁵, R Chase Cornelison^{4

5}, Lee W Tien⁶, R Carmen Preda⁶, Rebecca S Hayden⁶, Jacqueline K Chow⁵, Lindsey Nguy⁵, David L Kaplan⁷, Christine E Schmidt^{8

9}

Affiliations

¹ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. johnhardyuk@gmail.com.
² Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. johnhardyuk@gmail.com.
³ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. johnhardyuk@gmail.com.
⁴ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.
⁵ Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
⁶ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA.
⁷ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. david.kaplan@tufts.edu.
⁸ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. schmidt@bme.ufl.edu.
⁹ Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. schmidt@bme.ufl.edu.

PMID: 26033953
DOI: 10.1002/mabi.201500171

Instructive Conductive 3D Silk Foam-Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation

John G Hardy et al. Macromol Biosci. 2015 Nov.

. 2015 Nov;15(11):1490-6.

doi: 10.1002/mabi.201500171. Epub 2015 Jun 1.

Authors

Affiliations

¹ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. johnhardyuk@gmail.com.
² Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. johnhardyuk@gmail.com.
³ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. johnhardyuk@gmail.com.
⁴ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.
⁵ Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
⁶ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA.
⁷ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. david.kaplan@tufts.edu.
⁸ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. schmidt@bme.ufl.edu.
⁹ Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. schmidt@bme.ufl.edu.

PMID: 26033953
DOI: 10.1002/mabi.201500171

Abstract

Stimuli-responsive materials enabling the behavior of the cells that reside within them to be controlled are vital for the development of instructive tissue scaffolds for tissue engineering. Herein, we describe the preparation of conductive silk foam-based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells (HMSCs) to enhance their differentiation toward osteogenic outcomes.

Keywords: bone; conducting polymers; electrical stimulation; silk; stem cells.

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Instructive Conductive 3D Silk Foam-Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation

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Instructive Conductive 3D Silk Foam-Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation

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