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Comment
. 2015 Jun 1;212(6):829-30.
doi: 10.1084/jem.2126insight3.

Inflammation on the move

Niels Borregaard  1
Affiliations
Comment

Inflammation on the move

Niels Borregaard. J Exp Med. .
No abstract available

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Insight from Niels Borregaard
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Inflammasomes assemble on filamentous actin and generate IL-1β and IL-18. Wdr1 accelerates dissolution of filamentous actin and of the inflammasome. Mice hypomorphic for Wdr1 have more filamentous actin and their monocytes generate IL-1β and IL-18. The mice develop inflammation of cartillage tissue driven by IL-18, not by IL-1β.
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References

    1. Kim, M.L., et al. . 2015. J. Exp. Med. 10.1084/jem.20142384 - DOI

MeSH terms