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Review
. 2015 Dec;98(6):945-52.
doi: 10.1189/jlb.5MR0315-127R. Epub 2015 Jun 1.

The future of murine sepsis and trauma research models

Philip A Efron  1 , Alicia M Mohr  2 , Frederick A Moore  2 , Lyle L Moldawer  2
Affiliations
Review

The future of murine sepsis and trauma research models

Philip A Efron et al. J Leukoc Biol. 2015 Dec.

Abstract

Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini-review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma.

Keywords: immunity; translation.

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Figures

Figure 1.
Figure 1.. Comparison of previously used methodology for and our proposed future approach to rodent bench and human bedside sepsis and trauma research.
(A) The traditional paradigm of rodent sepsis and trauma research, which would eventually progress to human translational investigations. (B) Our proposal for future rodent sepsis and trauma studies. We recommend that investigators use “reverse translation” to prove that their methodology and/or rodent model is clinically relevant. This would be followed eventually by translational research from the rodent back to the human.
See this image and copyright information in PMC

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