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. 2015 Mar 23;2(1):ofv027.
doi: 10.1093/ofid/ofv027. eCollection 2015 Jan.

Ceftaroline desensitization procedure in a pregnant patient with multiple drug allergies

James L Kuhlen Jr  1 , Kimberly G Blumenthal  2 , Caroline L Sokol  3 , Diana S Balekian  1 , Ana A Weil  4 , Christy A Varughese  5 , Erica S Shenoy  6 , Aleena Banerji  1
Affiliations

Ceftaroline desensitization procedure in a pregnant patient with multiple drug allergies

James L Kuhlen Jr et al. Open Forum Infect Dis. .

Abstract

Validated skin testing is lacking for many drugs, including ceftaroline. The cross-reactivity between ceftaroline and other β-lactam antibiotics is unknown. We report a case of a pregnant patient with cystic fibrosis and multiple drug allergies who required ceftaroline for methicillin-resistant Staphylococcus aureus pneumonia and underwent an uncomplicated empiric desensitization procedure.

Keywords: ceftaroline; cross-reactivity; desensitization procedure; drug allergy; β-lactam.

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Figures

Figure 1.
Figure 1.
Chemical structure of β-lactam antibiotics. The chemical structures of ceftaroline as well as other β-lactam antibiotics to which the patient was allergic (amoxicillin, piperacillin, and cefepime). All structures contain a central β-lactam ring with distinct R groups.
See this image and copyright information in PMC

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