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Review
. 2015 Jul;173(1):R35-45.
doi: 10.1530/EJE-15-0013.

MANAGEMENT OF ENDOCRINE DISEASE: Paediatric Cushing's disease

Helen L Storr  1 , Martin O Savage  2
Affiliations
Review

MANAGEMENT OF ENDOCRINE DISEASE: Paediatric Cushing's disease

Helen L Storr et al. Eur J Endocrinol. 2015 Jul.

Abstract

Cushing's disease (CD) is the commonest form of ACTH-dependent Cushing's syndrome and is a rare clinical diagnosis in paediatric and adolescent patients. CD is caused by an ACTH-secreting pituitary corticotroph adenoma and is associated with significant morbidity in children; therefore, early diagnosis and treatment are critical for optimal therapeutic outcome. This review highlights the key clinical and biochemical features of paediatric CD and appraises current practices in diagnosis and management. A close liaison with adult endocrinology colleagues, particularly, for interpretation of investigations and definition of therapeutic strategy is strongly advised.

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