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Comment
. 2015 Jun;5(6):584-5.
doi: 10.1158/2159-8290.CD-15-0480.

Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress

Jingwei Sim  1 , Randall S Johnson  2
Affiliations
Comment

Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress

Jingwei Sim et al. Cancer Discov. 2015 Jun.

Abstract

Qiu and colleagues describe how a structural component of lipid droplets is markedly induced in pseudohypoxic renal tumors, where it maintains endoplasmic reticulum (ER) homeostasis. This adaptation is indispensable in tumor cells-where growth demands and a fluctuating blood supply place unnatural stresses on ER function-and is therefore an attractive therapeutic target.

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