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Comment
. 2015 Jun 2;21(6):793-4.
doi: 10.1016/j.cmet.2015.05.019.

Innate immune recognition of mtDNA--an undercover signal?

Thirumala-Devi Kanneganti  1 , Mondira Kundu  2 , Douglas R Green  3
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Innate immune recognition of mtDNA--an undercover signal?

Thirumala-Devi Kanneganti et al. Cell Metab. .
Free article

Abstract

In addition to their roles in cellular metabolism and apoptosis, mitochondria function as signaling platforms in the innate immune response. In Nature, West et al. (2015) demonstrate that mitochondrial stress triggers a type I interferon response and confers viral resistance via release of mtDNA and activation of the cGAS-STING pathway.

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  • Mitochondrial DNA stress primes the antiviral innate immune response.
    West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. West AP, et al. Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2. Nature. 2015. PMID: 25642965 Free PMC article.

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