Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul 20;34(16):2476-80.
doi: 10.1002/sim.6473.

No solution yet for combining two independent studies in the presence of heterogeneity

Andrea Gonnermann  1 , Theodor Framke  1 , Anika Großhennig  1 , Armin Koch  1
Affiliations

No solution yet for combining two independent studies in the presence of heterogeneity

Andrea Gonnermann et al. Stat Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a–d): Influence of heterogeneity in meta-analysis with two and six studies on empirical power. FE, fixed effects approach; DL, DerSimonian and Laird approach; HK, Hartung and Knapp approach. In the left column, simulation results with two studies are presented, whereas in the right column, situations with six studies are investigated. No heterogeneity is assumed in the top row, and in the bottom row, the impact of moderate heterogeneity is shown.
See this image and copyright information in PMC

References

    1. Jackson D, Baker R. Meta-analysis inside and outside particle physics: convergence using the path of least resistance? Research Synthesis Methods. 2013;4:125–126. - PubMed
    1. Hartung J, Knapp G. A refined method for the meta-analysis of controlled clinical trials with binary outcome. Statistics in Medicine. 2001;20(3):875–3889. - PubMed
    1. Hartung J, Knapp G. On tests of the overall treatment effect in meta-analysis with normally distributed responses. Statistics in Medicine. 2001;20:1771–1782. - PubMed
    1. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials. 1986;7:177–188. available at 10.1016/0197-2456(86)90046-2. - DOI - PubMed
    1. Villar J, Mackey M. Meta-analyses in systematic reviews of randomized controlled trials in perinatal medicine: comparison of fixed and random effects models. Statistics in Medicine. 2001;20:3635–3647. - PubMed

Publication types

LinkOut - more resources