Global implementation of genomic medicine: We are not alone

Teri A Manolio¹, Marc Abramowicz², Fahd Al-Mulla³, Warwick Anderson⁴, Rudi Balling⁵, Adam C Berger⁶, Steven Bleyl⁷, Aravinda Chakravarti⁸, Wasun Chantratita⁹, Rex L Chisholm¹⁰, Vajira H W Dissanayake¹¹, Michael Dunn¹², Victor J Dzau¹³, Bok-Ghee Han¹⁴, Tim Hubbard¹⁵, Anne Kolbe¹⁶, Bruce Korf¹⁷, Michiaki Kubo¹⁸, Paul Lasko¹⁹, Erkki Leego²⁰, Surakameth Mahasirimongkol²¹, Partha P Majumdar²², Gert Matthijs²³, Howard L McLeod²⁴, Andres Metspalu²⁰, Pierre Meulien²⁵, Satoru Miyano²⁶, Yaakov Naparstek²⁷, P Pearl O'Rourke²⁸, George P Patrinos²⁹, Heidi L Rehm³⁰, Mary V Relling³¹, Gad Rennert³², Laura Lyman Rodriguez³³, Dan M Roden³⁴, Alan R Shuldiner³⁵, Sukdeb Sinha³⁶, Patrick Tan³⁷, Mats Ulfendahl³⁸, Robyn Ward³⁹, Marc S Williams⁴⁰, John E L Wong⁴¹, Eric D Green³³, Geoffrey S Ginsburg⁴²

Affiliations

¹ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-9305, USA. manolio@nih.gov geoffrey.ginsburg@dm.duke.edu.
² Université Libre de Bruxelles 1070 Brussels, Belgium.
³ Genatak-Global Med Clinic, Kuwait University, Kuwait 46300, Kuwait.
⁴ National Health and Medical Research Council, Canberra, ACT 2601, Australia.
⁵ Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, L-4362 Luxembourg.
⁶ Board on Health Sciences Policy, Institute of Medicine, Washington, DC 20001, USA.
⁷ Intermountain Healthcare, Salt Lake City, UT 84111, USA.
⁸ McKusick-Nathans Institute of Genetic Medicine, John Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁹ Ramathibodi Hospital, Mahidol University, Bangkok, 10400 Thailand.
¹⁰ Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
¹¹ Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka.
¹² Genetic and Molecular Sciences, The Wellcome Trust, London NW1 2BE, UK.
¹³ National Academy of Medicine, Washington, DC 20001, USA.
¹⁴ Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 363-951 Korea.
¹⁵ Department of Medical and Molecular Genetics, King's College, London SE1 9RT, and Genomics England, London EC1M 6BQ, UK.
¹⁶ National Health Committee, Auckland 1050, New Zealand.
¹⁷ Center for Genomic Science, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
¹⁸ Center for Integrative Medical Science (IMS), RIKEN, Yokohama 230-0045, Japan.
¹⁹ Institute of Genetics, Canadian Institutes of Health Research, and McGill University, Montreal, Quebec, H3A 0G4 Canada.
²⁰ Estonian Genome Center, University of Tartu, Tartu 51010 Estonia.
²¹ Department of Medical Science, Ministry of Public Health, Nonthaburi 11000 Thailand.
²² National Institute of Biomedical Genomics and Indian Statistical Institute, Kalyani 741251 India.
²³ Center for Human Genetics, University of Leuven (KU Leuven), B-3000 Leuven, Belgium.
²⁴ DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, FL 33612 USA.
²⁵ Genome Canada, Ottawa, Ontario K2P 1P1, Canada.
²⁶ Institute of Medical Science, University of Tokyo, 108-8639 Tokyo, Japan.
²⁷ Research and Academic Affairs, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel.
²⁸ Office of Human Research Affairs, Partners HealthCare, Boston, MA 02199, USA.
²⁹ Department of Pharmacy, School of Health Sciences, University of Patras, Patras, 26504 Greece.
³⁰ Laboratory for Molecular Medicine, Partners Healthcare Systems, Boston, MA 02139, USA.
³¹ Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
³² Carmel Medical Center Department of Community Medicine and Epidemiology, Clalit National Personalized Medicine Program, Haifa 34362, Israel.
³³ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-9305, USA.
³⁴ Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
³⁵ Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
³⁶ Department of Biotechnology, Ministry of Science and Technology, Govt., New Delhi 110 003 India.
³⁷ Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.
³⁸ Swedish Research Council, SE-101 38 Stockholm, Sweden.
³⁹ University of Queensland, St. Lucia, QLD 4067 Australia.
⁴⁰ Genomic Medicine Institute, Geisinger Health System, Danville, PA 18510, USA.
⁴¹ National University of Singapore, Singapore 119228, Singapore.
⁴² Center for Applied Genomics and Precision Medicine, Duke University, Durham, NC 27710, USA. manolio@nih.gov geoffrey.ginsburg@dm.duke.edu.

PMID: 26041702
PMCID: PMC4898888
DOI: 10.1126/scitranslmed.aab0194

Review

Global implementation of genomic medicine: We are not alone

Teri A Manolio et al. Sci Transl Med. 2015.

. 2015 Jun 3;7(290):290ps13.

doi: 10.1126/scitranslmed.aab0194.

Authors

Affiliations

¹ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-9305, USA. manolio@nih.gov geoffrey.ginsburg@dm.duke.edu.
² Université Libre de Bruxelles 1070 Brussels, Belgium.
³ Genatak-Global Med Clinic, Kuwait University, Kuwait 46300, Kuwait.
⁴ National Health and Medical Research Council, Canberra, ACT 2601, Australia.
⁵ Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, L-4362 Luxembourg.
⁶ Board on Health Sciences Policy, Institute of Medicine, Washington, DC 20001, USA.
⁷ Intermountain Healthcare, Salt Lake City, UT 84111, USA.
⁸ McKusick-Nathans Institute of Genetic Medicine, John Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁹ Ramathibodi Hospital, Mahidol University, Bangkok, 10400 Thailand.
¹⁰ Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
¹¹ Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka.
¹² Genetic and Molecular Sciences, The Wellcome Trust, London NW1 2BE, UK.
¹³ National Academy of Medicine, Washington, DC 20001, USA.
¹⁴ Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 363-951 Korea.
¹⁵ Department of Medical and Molecular Genetics, King's College, London SE1 9RT, and Genomics England, London EC1M 6BQ, UK.
¹⁶ National Health Committee, Auckland 1050, New Zealand.
¹⁷ Center for Genomic Science, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
¹⁸ Center for Integrative Medical Science (IMS), RIKEN, Yokohama 230-0045, Japan.
¹⁹ Institute of Genetics, Canadian Institutes of Health Research, and McGill University, Montreal, Quebec, H3A 0G4 Canada.
²⁰ Estonian Genome Center, University of Tartu, Tartu 51010 Estonia.
²¹ Department of Medical Science, Ministry of Public Health, Nonthaburi 11000 Thailand.
²² National Institute of Biomedical Genomics and Indian Statistical Institute, Kalyani 741251 India.
²³ Center for Human Genetics, University of Leuven (KU Leuven), B-3000 Leuven, Belgium.
²⁴ DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, FL 33612 USA.
²⁵ Genome Canada, Ottawa, Ontario K2P 1P1, Canada.
²⁶ Institute of Medical Science, University of Tokyo, 108-8639 Tokyo, Japan.
²⁷ Research and Academic Affairs, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel.
²⁸ Office of Human Research Affairs, Partners HealthCare, Boston, MA 02199, USA.
²⁹ Department of Pharmacy, School of Health Sciences, University of Patras, Patras, 26504 Greece.
³⁰ Laboratory for Molecular Medicine, Partners Healthcare Systems, Boston, MA 02139, USA.
³¹ Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
³² Carmel Medical Center Department of Community Medicine and Epidemiology, Clalit National Personalized Medicine Program, Haifa 34362, Israel.
³³ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-9305, USA.
³⁴ Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
³⁵ Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
³⁶ Department of Biotechnology, Ministry of Science and Technology, Govt., New Delhi 110 003 India.
³⁷ Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.
³⁸ Swedish Research Council, SE-101 38 Stockholm, Sweden.
³⁹ University of Queensland, St. Lucia, QLD 4067 Australia.
⁴⁰ Genomic Medicine Institute, Geisinger Health System, Danville, PA 18510, USA.
⁴¹ National University of Singapore, Singapore 119228, Singapore.
⁴² Center for Applied Genomics and Precision Medicine, Duke University, Durham, NC 27710, USA. manolio@nih.gov geoffrey.ginsburg@dm.duke.edu.

PMID: 26041702
PMCID: PMC4898888
DOI: 10.1126/scitranslmed.aab0194

Abstract

Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual efforts might benefit from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Efforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in efforts to improve clinical care worldwide.

PubMed Disclaimer

References

1. McCarthy JJ, McLeod HL, Ginsburg GS. Genomic medicine: a decade of successes, challenges, and opportunities. Sci Transl Med. 2013 Jun 12;5(189):189sr4. - PubMed
1. Mardis E. A decade’s perspective on DNA sequencing technology. Nature. 2011;470:198–203. - PubMed
1. Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O’Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, Ginsburg GS. Implementing genomic medicine in the clinic: the future is here. Genet Med. 2013 Apr;15(4):258–67. - PMC - PubMed
1. Embi PJ, Payne PR. Evidence generating medicine: redefining the research-practice relationship to complete the evidence cycle. Med Care. 2013 Aug;51(8 Suppl 3):S87–91. - PubMed
1. Human Genomics Strategy Group. [accessed 2/15/14];Building on our Inheritance: Genomic Technology in Healthcare. https://www.gov.uk/government/uploads/system/uploads/attachment_data/fil....

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Global implementation of genomic medicine: We are not alone

Affiliations

Global implementation of genomic medicine: We are not alone

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources