Neuroendocrine neoplasms of the sinonasal region

Diana Bell^{1

2}, Ehab Y Hanna², Randal S Weber², Franco DeMonte³, Asterios Triantafyllou⁴, James S Lewis Jr⁵, Antonio Cardesa⁶, Pieter J Slootweg⁷, Göran Stenman⁸, Douglas R Gnepp⁹, Kenneth O Devaney¹⁰, Juan P Rodrigo^{11

12}, Alessandra Rinaldo¹³, Bruce M Wenig¹⁴, William H Westra¹⁵, Justin A Bishop¹⁵, Henrik Hellquist¹⁶, Jennifer L Hunt¹⁷, Kimihide Kusafuka¹⁸, Bayardo Perez-Ordoñez^{19

20}, Michelle D Williams¹, Robert P Takes²¹, Alfio Ferlito²²

Affiliations

¹ Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
² Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
³ Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
⁴ Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Cellular Pathology, University Hospital Aintree, Liverpool, United Kingdom.
⁵ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
⁶ Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁷ Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁸ Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg, Sweden.
⁹ Head and Neck Pathology, University Pathologists, Warwick, Rhode Island and Fall River, Massachusetts.
¹⁰ Department of Pathology, Allegiance Health, Jackson, Michigan.
¹¹ Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
¹² Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
¹³ University of Udine School of Medicine, Udine, Italy.
¹⁴ Department of Pathology, Beth Israel Medical Center, New York, New York.
¹⁵ Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
¹⁶ Departamento de Ciências, Biomédicas e Medicina, Universidade do Algavre, Faro, Portugal.
¹⁷ Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
¹⁸ Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
¹⁹ Department of Pathology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
²⁰ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
²¹ Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
²² Coordinator of the International Head and Neck Scientific Group.

PMID: 26041714
DOI: 10.1002/hed.24152

Review

Neuroendocrine neoplasms of the sinonasal region

Diana Bell et al. Head Neck. 2016 Apr.

. 2016 Apr:38 Suppl 1:E2259-66.

doi: 10.1002/hed.24152. Epub 2015 Jul 18.

Authors

Affiliations

¹ Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
² Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
³ Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
⁴ Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Cellular Pathology, University Hospital Aintree, Liverpool, United Kingdom.
⁵ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
⁶ Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁷ Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁸ Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg, Sweden.
⁹ Head and Neck Pathology, University Pathologists, Warwick, Rhode Island and Fall River, Massachusetts.
¹⁰ Department of Pathology, Allegiance Health, Jackson, Michigan.
¹¹ Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
¹² Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
¹³ University of Udine School of Medicine, Udine, Italy.
¹⁴ Department of Pathology, Beth Israel Medical Center, New York, New York.
¹⁵ Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
¹⁶ Departamento de Ciências, Biomédicas e Medicina, Universidade do Algavre, Faro, Portugal.
¹⁷ Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
¹⁸ Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
¹⁹ Department of Pathology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
²⁰ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
²¹ Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
²² Coordinator of the International Head and Neck Scientific Group.

PMID: 26041714
DOI: 10.1002/hed.24152

Abstract

Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2259-E2266, 2016.

Keywords: immunohistochemistry; neuroendocrine neoplasms; olfactory neuroblastoma; sinonasal carcinoma; sinonasal undifferentiated carcinoma.

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Neuroendocrine neoplasms of the sinonasal region

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Neuroendocrine neoplasms of the sinonasal region

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Abstract

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