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Comment
. 2015;11(7):1192-5.
doi: 10.1080/15548627.2015.1054594.

Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation

Yanju Tong  1 , Fuyong Song
Affiliations
Comment

Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation

Yanju Tong et al. Autophagy. 2015.

Abstract

The transcription-regulating activity of TFEB is dependent on its phosphorylation modification, but the phosphatase(s) involved in TFEB dephosphorylation have remained elusive. It has now become clear that lysosomal calcium signaling activates calcineurin, an endogenous serine/threonine phosphatase, which dephosphorylate TFEB leading to upregulation of autophagy.

Keywords: calcineurin; calcium signaling; transcription factor EB.

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Figures

Figure 1.
Figure 1.
Regulation of TFEB activity by intracellular calcium signaling. Extra- and intracellular stimuli induce elevation of cytoplasmic Ca2+ levels by releasing Ca2+ from the lysosome. Elevated cytosol Ca2+ can suppress MTORC1-dependent pathways, and (or) activate calcineurin-dependent pathways, subsequently inducing dephosphorylation of TFEB, and resulting in the activation of autophagy.
See this image and copyright information in PMC

Comment on

  • Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.
    Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto-Rosato A, Prezioso C, Forrester A, Settembre C, Wang W, Gao Q, Xu H, Sandri M, Rizzuto R, De Matteis MA, Ballabio A. Medina DL, et al. Nat Cell Biol. 2015 Mar;17(3):288-99. doi: 10.1038/ncb3114. Nat Cell Biol. 2015. PMID: 25720963 Free PMC article.

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