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Comment
. 2015;11(7):1189-91.
doi: 10.1080/15548627.2015.1054595.

Hepatocyte-specific Hmgb1 Deletion

Xiaofang Sun  1 , Daolin Tang
Affiliations
Comment

Hepatocyte-specific Hmgb1 Deletion

Xiaofang Sun et al. Autophagy. 2015.

Abstract

High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Cre-lox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 (flox)/(flox) mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.

Keywords: HMGB1, knockout, liver, mice.

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References

    1. Sun X, Tang D. HMGB1-dependent and -independent autophagy. Autophagy 2014; 10:1873-6; PMID:25126737; http://dx.doi.org/10.4161/auto.32184 - DOI - PMC - PubMed
    1. Huang H, Nace GW, McDonald KA, Tai S, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, et al.. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. Hepatology 2014; 59:1984-97; PMID:24375466; http://dx.doi.org/10.1002/hep.26976 - DOI - PMC - PubMed
    1. Huebener P, Gwak GY, Pradere JP, Quinzii CM, Friedman R, Lin CS, Trent CM, Mederacke I, Zhao E, Dapito DH, et al.. High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab 2014; 19:539-47; PMID:24606906; http://dx.doi.org/10.1016/j.cmet.2014.01.014 - DOI - PMC - PubMed
    1. Huebener P, Pradere JP, Hernandez C, Gwak GY, Caviglia JM, Mu X, Loike JD, Jenkins RE, Antoine DJ, Schwabe RF. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest 2015; 125:539-50; PMID:25562324; http://dx.doi.org/10.1172/JCI76887 - DOI - PMC - PubMed
    1. Ge X, Antoine DJ, Lu Y, Arriazu E, Leung TM, Klepper AL, Branch AD, Fiel MI, Nieto N. High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD). J Biol Chem 2014; 289:22672-91; PMID:24928512; http://dx.doi.org/10.1074/jbc.M114.552141 - DOI - PMC - PubMed

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