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Comment
. 2015 Jun 5;348(6239):1094-5.
doi: 10.1126/science.aac5832.

Epigenetics. Exceptional epigenetics in the brain

Chongyuan Luo  1 , Joseph R Ecker  2
Affiliations
Comment

Epigenetics. Exceptional epigenetics in the brain

Chongyuan Luo et al. Science. .

Abstract

Non-CG DNA methylation modulates gene expression in the adult brain

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Figures

Figure
Figure. Brain methylation
The current model focuses on mCG at discrete regulatory elements in the genome, where it may block the binding of a transcription factor (TF) or bind to MeCP2, which represses transcription. The model does not inform about epigenomic differences between newborn and adult brains. The revised model highlights the accumulation of mCH, which is initiated at birth and continues throughout adolescence, resulting in a distinct state in the adult brain with high-affinity interaction between mCA and MeCP2. The recruitment of MeCP2 (and perhaps other mCH “readers” indicated with “?”) by non-CG methylation represses the expression of genes enriched in mCA, possibly by affecting transcription elongation. Pol2, RNA polymerase 2.
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