DUB-ling down on B-cell malignancies
- PMID: 26045592
- DOI: 10.1182/blood-2015-04-638262
DUB-ling down on B-cell malignancies
Abstract
In this issue of Blood, Peterson et al demonstrate that inhibition of both Usp9x and Usp24 results in efficient degradation of Mcl-1, induction of apoptosis, and inhibition of tumor growth in B-cell malignancies.
Comment on
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Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.Blood. 2015 Jun 4;125(23):3588-97. doi: 10.1182/blood-2014-10-605584. Epub 2015 Mar 26. Blood. 2015. PMID: 25814533
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