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Comment
. 2015 Jun 4;125(23):3523-5.
doi: 10.1182/blood-2015-04-640649.

A paradigm shift in platelet transfusion therapy

Jaehyung Cho  1
Affiliations
Comment

A paradigm shift in platelet transfusion therapy

Jaehyung Cho. Blood. .

Abstract

In this issue of Blood, Wang et al report that ex vivo–derived human megakaryocytes infused into mice are trapped in the pulmonary vasculature and release functional platelets into the circulation. Because of the difficulty in scalable generation of ex vivo–derived functional platelets, this strategy may be a substitute for platelet transfusion therapy.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Future of platelet transfusion therapy. (A) Because of numerous concerns about donor-derived platelets, stem cell–derived platelets may be a potential source for transfusion. (B) Instead of generating platelets from human embryonic or induced pluripotent stem cells ex vivo, Wang et al demonstrated that ex vivo–derived human megakaryocytes infused into mice can release functional platelets into the circulation. Professional illustration by Luk Cox, Somersault18:24.
See this image and copyright information in PMC

Comment on

References

    1. Wang Y, Hayes V, Jarocha D, et al. Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. Blood. 2015;125(23):3627–3636. - PMC - PubMed
    1. Kaushansky K. Historical review: megakaryopoiesis and thrombopoiesis. Blood. 2008;111(3):981–986. - PMC - PubMed
    1. Zucker-Franklin D, Philipp CS. Platelet production in the pulmonary capillary bed: new ultrastructural evidence for an old concept. Am J Pathol. 2000;157(1):69–74. - PMC - PubMed
    1. Fuentes R, Wang Y, Hirsch J, et al. Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest. 2010;120(11):3917–3922. - PMC - PubMed
    1. Takayama N, Nishimura S, Nakamura S, et al. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med. 2010;207(13):2817–2830. - PMC - PubMed