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Review
. 2015 Feb 1;128(3):423-9.
doi: 10.1242/jcs.083246.

The nuclear pore complex--structure and function at a glance

Greg Kabachinski, Thomas U Schwartz
Review

The nuclear pore complex--structure and function at a glance

Greg Kabachinski et al. J Cell Sci. .

Abstract

Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this Cell Science at a Glance article and the accompanying poster, we discuss how transport between the nucleoplasm and the cytoplasm is regulated, what we currently know about the structure of individual nucleoporins and the assembled NPC, and how the cell regulates assembly and disassembly of such a massive structure. Our aim is to provide a general overview on what we currently know about the nuclear pore and point out directions of research this area is heading to.

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References

    1. Alber F., Dokudovskaya S., Veenhoff L. M., Zhang W., Kipper J., Devos D., Suprapto A., Karni-Schmidt O., Williams R., Chait B. T. et al. (2007). The molecular architecture of the nuclear pore complex. Nature 450, 695–701 10.1038/nature06405 - DOI - PubMed
    1. Andersen K. R., Onischenko E., Tang J. H., Kumar P., Chen J. Z., Ulrich A., Liphardt J. T., Weis K., Schwartz T. U. (2013). Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors. eLife 2, e00745 10.7554/eLife.00745 - DOI - PMC - PubMed
    1. Atkinson C. E., Mattheyses A. L., Kampmann M., Simon S. M. (2013). Conserved spatial organization of FG domains in the nuclear pore complex. Biophys. J. 104, 37–50 10.1016/j.bpj.2012.11.3823 - DOI - PMC - PubMed
    1. Beck M., Förster F., Ecke M., Plitzko J. M., Melchior F., Gerisch G., Baumeister W., Medalia O. (2004). Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Science 306, 1387–1390 10.1126/science.1104808 - DOI - PubMed
    1. Bonnet A., Palancade B. (2014). Regulation of mRNA trafficking by nuclear pore complexes. Genes (Basel) 5, 767–791 10.3390/genes5030767 - DOI - PMC - PubMed

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