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Comment
. 2015 Jun 5:4:e08659.
doi: 10.7554/eLife.08659.

An alternative to force

Amanda Patel  1 , Sophie Demolombe  1 , Eric Honoré  1
Affiliations
Comment

An alternative to force

Amanda Patel et al. Elife. .

Abstract

Researchers have discovered a synthetic small molecule that activates a mechanosensitive ion channel involved in a blood disorder.

Keywords: agonist; biophysics; cell volume regulation; ion channel; mechanotransduction; mouse; neuroscience; physiology; red blood cells; structural biology.

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Conflict of interest statement

Competing interests:The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. Ion channels and red blood cells.
(Left) Opening the Piezo1 ion channel (green) by mechanical stress or by the synthetic small molecule Yoda1 promotes an influx of calcium ions that stimulates the opening of the KCa3.1 Gardos channel (blue). The resulting efflux of potassium ions through the KCa3.1 Gardos channel leads to a loss of water from the red blood cell, which causes it to shrink. Mutations in the Piezo1 gene reduce the ability of the Piezo1 ion channel to close, which causes red blood cells to shrink in the disease xerocytosis. Excessive opening of the Piezo1 ion channel might also be involved in sickle cell disease. (Right) When the gene for Piezo1 is deleted, there is no influx of calcium ions, so the KCa3.1 Gardos channel remains closed and the cell becomes overhydrated. Red blood cells that lack the KCa3.1 Gardos channel also become overhydrated (not shown; Grgic et al., 2009).
See this image and copyright information in PMC

Comment on

  • Chemical activation of the mechanotransduction channel Piezo1.
    Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A. Syeda R, et al. Elife. 2015 May 22;4:e07369. doi: 10.7554/eLife.07369. Elife. 2015. PMID: 26001275 Free PMC article.

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