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doi: 10.1016/j.cell.2015.05.039.
Forget the Parents: Epigenetic Reprogramming in Human Germ Cells
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- PMID: 26046435
- DOI: 10.1016/j.cell.2015.05.039
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Forget the Parents: Epigenetic Reprogramming in Human Germ Cells
Cell.
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Abstract
Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the transcriptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptional network and progressive and conserved global erasure of DNA methylation.
Copyright © 2015 Elsevier Inc. All rights reserved.
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The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.Nat Cell Biol. 2013 Jan;15(1):113-22. doi: 10.1038/ncb2638. Epub 2012 Dec 16. Nat Cell Biol. 2013. PMID: 23242216 Free PMC article.
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The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells.Cell. 2015 Jun 4;161(6):1437-52. doi: 10.1016/j.cell.2015.05.015. Cell. 2015. PMID: 26046443
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A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.Cell. 2015 Jun 4;161(6):1453-67. doi: 10.1016/j.cell.2015.04.053. Cell. 2015. PMID: 26046444 Free PMC article.
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