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Comment
. 2015 Jun 4;16(6):576-7.
doi: 10.1016/j.stem.2015.05.010.

Regenerative Medicines for Remyelination: From Aspiration to Reality

Robin J M Franklin  1
Affiliations
Free article
Comment

Regenerative Medicines for Remyelination: From Aspiration to Reality

Robin J M Franklin. Cell Stem Cell. .
Free article

Abstract

Stimulating an endogenous regenerative response is a powerful approach for potential treatment of chronic demyelinating diseases such as multiple sclerosis. Recently in Nature, Najm et al. (2015) identified two clinically relevant, FDA-approved compounds that promote oligodendrocyte progenitor cell differentiation and induce remyelination in demyelinating disease models.

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  • Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
    Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ. Najm FJ, et al. Nature. 2015 Jun 11;522(7555):216-20. doi: 10.1038/nature14335. Epub 2015 Apr 20. Nature. 2015. PMID: 25896324 Free PMC article.

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