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. 2015 Oct;45(10):3183-94.
doi: 10.1007/s10803-015-2476-8.

Autism spectrum disorder symptoms among children enrolled in the Study to Explore Early Development (SEED)

Lisa D Wiggins  1 , Susan E Levy  2   3 , Julie Daniels  4 , Laura Schieve  5 , Lisa A Croen  6 , Carolyn DiGuiseppi  7 , Lisa Blaskey  2 , Ellen Giarelli  2   8 , Li-Ching Lee  9 , Jennifer Pinto-Martin  10 , Ann Reynolds  11 , Catherine Rice  5   12 , Cordelia Robinson Rosenberg  11 , Patrick Thompson  13 , Marshalyn Yeargin-Allsopp  5 , Lisa Young  10 , Diana Schendel  5   14   15   16
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Autism spectrum disorder symptoms among children enrolled in the Study to Explore Early Development (SEED)

Lisa D Wiggins et al. J Autism Dev Disord. 2015 Oct.

Abstract

This study examined the phenotypic profiles of children aged 30-68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses.

Keywords: Autism; Etiology; Phenotype; Study to Explore Early Development; Symptoms.

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Figures

Fig. 1
Fig. 1
Participant selection criteria for the 2600 children described in these analyses
See this image and copyright information in PMC

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