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Review
. 2015 Jul;18(4):367-73.
doi: 10.1097/MCO.0000000000000186.

The potential regulatory role of vitamin D in the bioenergetics of inflammation

Emily K Calton  1 , Kevin N Keane, Mario J Soares
Affiliations
Review

The potential regulatory role of vitamin D in the bioenergetics of inflammation

Emily K Calton et al. Curr Opin Clin Nutr Metab Care. 2015 Jul.

Abstract

Purpose of review: The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of inflammation, offer an avenue to cement the regulatory role of vitamin D in this process.

Recent findings: Nuclear vitamin D receptors may be translocated into mitochondria of certain cell types, opening up a pathway for direct action on cellular bioenergetics. Classical M1 (inflammatory)/M2(anti-inflammatory) phenotypes can vary with the clinical context. M2 macrophages do not always depend on oxidative metabolism/fatty acid oxidation. Newer methodologies offer real-time bioenergetic measurements that can be used as an index of metabolic health.

Summary: Vitamin D may prove to be a therapeutic agent for inflammation of chronic disease and understanding its role in cellular bioenergetics may offer a diagnostic/prognostic indicator of its action.

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