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Review
. 2015 Jul;10(4):226-32.
doi: 10.1097/COH.0000000000000170.

The current status of the use of oral medication to prevent HIV transmission

Kenneth H Mayer  1 , Gita Ramjee
Affiliations
Review

The current status of the use of oral medication to prevent HIV transmission

Kenneth H Mayer et al. Curr Opin HIV AIDS. 2015 Jul.

Abstract

Purpose of review: This review was designed to evaluate the progress in studies of the use of oral and topical antiretroviral (ARV) medication for primary HIV prevention.

Recent findings: Nonhuman primate data have suggested that the administration of ARV medication before or after retroviral exposure can protect against the establishment of chronic infection. Over the past two decades, observational studies have demonstrated the safety of ARV agents for postexposure prophylaxis and more recent efficacy studies have demonstrated that tenofovir with or without emtricitabine can protect against HIV when used as preexposure prophylaxis (PrEP). Efficacy studies have been conducted in diverse populations, including men and transgender women who have sex with men, young African heterosexuals, and injection drug users. Three studies in African women evaluating oral and topical tenofovir-based regimens did not demonstrate efficacy, in large part because of suboptimal medication adherence. Further research is underway to determine the optimal ways to provide chemoprophylaxis, the optimal medications, and dosing regimens.

Summary: PrEP can be effective in decreasing HIV transmission to at-risk uninfected persons, but further research is needed to determine the optimal modes of delivery.

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Conflict of interest statement

Dr. Mayer has received unrestricted research grants from Gilead Sciences.

Figures

Figure One
Figure One
Clinical Trial Evidence for Oral and Topical Tenofovir-Based Prevention [12] Content was adapted from AVAC Report 2013: Research & Reality, published by AVAC (www.avac.org)
See this image and copyright information in PMC

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