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Case Reports
. 2015 Oct;122(10):2142-5.
doi: 10.1016/j.ophtha.2015.04.026. Epub 2015 Jun 6.

Varicella Zoster Virus in Ischemic Optic Neuropathy

Liliya Golas  1 , Jeffrey L Bennett  2 , Teresa M White  3 , Barry Skarf  4 , Robert Lesser  5 , Maria A Nagel  3 , Don Gilden  6
Affiliations
Case Reports

Varicella Zoster Virus in Ischemic Optic Neuropathy

Liliya Golas et al. Ophthalmology. 2015 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Varicella zoster virus (VZV) in temporal arteries from patients with anterior ischemic optic neuropathy (AION). One-hundred 5-μm sections from each TA were cut and baked for 1 hour at 60°C. Every other slide (50 sections/TA) was deparaffinized and immunostained with either mouse anti-VZV glycoprotein E (a late viral protein indicative of productive infection) IgG1 antibody or control mouse IgG1 antibody (Dako) and examined by light microscopy; if VZV antigen was detected, adjacent sections were stained with hematoxylin and eosin and examined histologically, as described. VZV was detected in 5 temporal arteries from patients with AION. VZV antigen was seen in the adventitia of a positive control VZV-infected cadaveric cerebral artery (A, pink) 14 days post-infection in vitro. Note VZV antigen in cells adjacent to the internal elastic lamina of patient 2 (B), in the adventitia of patient 3 (C), in the adventitia and media of patient 4 (G), in the adventitia, media and intima of patient 5 (H), and in the media of patient 6 (I). No staining was seen in sections adjacent to those containing VZV antigen when mouse IgG1 antibody was substituted for mouse anti-VZV gE IgG1 antibody (D-F, J-L). Magnification 600X.
See this image and copyright information in PMC

References

    1. Nagel MA, Khmeleva N, Boyer PJ, et al. Varicella zoster virus in the temporal artery of a patient with giant cell arteritis. J Neurol Sci. 2013;335:228–30. - PMC - PubMed
    1. Nagel MA, Russman AN, Feit DO, et al. VZV ischemic optic neuropathy and subclinical temporal artery infection without rash. Neurology. 2013;80:220–2. - PMC - PubMed
    1. Nagel MA, Bennett JL, Khmeleva N, et al. Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis. Neurology. 2013;80:2017–21. - PMC - PubMed
    1. Mathias M, Nagel MA, Khmeleva N, et al. VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash. J Neurol Sci. 2013;325:180–2. - PMC - PubMed
    1. Gilden D, White T, Khmeleva N, et al. Prevalence and distribution of varicella zoster virus in temporal arteries of patients with giant cell arteritis. Neurology. 2015 Feb 18;:pii. 10.1212/WNL.0000000000001409.

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