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Randomized Controlled Trial
. 2015 Aug 15;192(4):523-5.
doi: 10.1164/rccm.201502-0235LE.

Blood Eosinophils: A Biomarker of Response to Extrafine Beclomethasone/Formoterol in Chronic Obstructive Pulmonary Disease

Affiliations
Randomized Controlled Trial

Blood Eosinophils: A Biomarker of Response to Extrafine Beclomethasone/Formoterol in Chronic Obstructive Pulmonary Disease

Salman H Siddiqui et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Adjusted chronic obstructive pulmonary disease (COPD) exacerbation rate (events/patient/year) with beclomethasone dipropionate plus formoterol fumarate (BDP/FF) (black) and FF (gray) stratified by baseline blood eosinophil (EOS) quartile. (B) Adjusted mean difference from baseline to 48 weeks with BDP/FF (black) and FF (gray) in predose morning FEV1 (L) at 48 weeks stratified by baseline blood EOS quartile. (C) Adjusted mean difference from baseline to 48 weeks with BDP/FF (black) and FF (gray) in total St. George’s Respiratory Questionnaire (SGRQ) at 48 weeks, stratified by baseline blood EOS quartile.

References

    1. Agusti A. The path to personalised medicine in COPD. Thorax. 2014;69:857–864. - PubMed
    1. Singh D, Kolsum U, Brightling CE, Locantore N, Agusti A, Tal-Singer R ECLIPSE investigators. Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur Respir J. 2014;44:1697–1700. - PubMed
    1. Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184:662–671. - PubMed
    1. Papi A, Bellettato CM, Braccioni F, Romagnoli M, Casolari P, Caramori G, Fabbri LM, Johnston SL. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med. 2006;173:1114–1121. - PubMed
    1. Bafadhel M, McKenna S, Terry S, Mistry V, Pancholi M, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2012;186:48–55. - PMC - PubMed

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