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. 2015 Jul 11;51(54):10831-4.
doi: 10.1039/c5cc03028e.

A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics

Lei Zhang  1 , Jianping Lei, Fengjiao Ma, Pinghua Ling, Jintong Liu, Huangxian Ju
Affiliations

A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics

Lei Zhang et al. Chem Commun (Camb). .

Abstract

A photosensitized and caspase-responsive multifunctional nanoprobe was designed by assembling a porphyrin, a folate targeting-motif and a dye-labelled peptide in a metal-organic framework (MOF) cage, which significantly increases the singlet oxygen quantum yield of porphyrin by 6.2 times, and achieves high efficient cancer therapy and in situ therapeutic monitoring with caspase-3 activation. The integration of theranostic functions in a single nanocarrier holds great promise in precision cancer diagnosis and treatment.

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