Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases

James R Stone¹, Patrick Bruneval², Annalisa Angelini³, Giovanni Bartoloni⁴, Cristina Basso³, Lubov Batoroeva⁵, L Maximilian Buja⁶, Jagdish Butany⁷, Giulia d'Amati⁸, John T Fallon⁹, Adriana C Gittenberger-de Groot¹⁰, Rosa H Gouveia¹¹, Marc K Halushka¹², Karen L Kelly¹³, Ivana Kholova¹⁴, Ornella Leone¹⁵, Silvio H Litovsky¹⁶, Joseph J Maleszewski¹⁷, Dylan V Miller¹⁸, Richard N Mitchell¹⁹, Stephen D Preston²⁰, Angela Pucci²¹, Stanley J Radio²², E Rene Rodriguez²³, Mary N Sheppard²⁴, S Kim Suvarna²⁵, Carmela D Tan²³, Gaetano Thiene³, Allard C van der Wal²⁶, John P Veinot²⁷

Affiliations

¹ Massachusetts General Hospital, Boston, MA, USA. Electronic address: jrstone@partners.org.
² University Paris-Descartes, France. Electronic address: patrick.bruneval@egp.aphp.fr.
³ University of Padua Medical School, Padua, Italy.
⁴ University of Catania, Catania, Italy.
⁵ Russian Academy of Medical Sciences, Irkutsk, Russia.
⁶ University of Texas Health Science Center at Houston, Houston, TX, USA.
⁷ Toronto General Hospital, Toronto, Canada.
⁸ Sapienza, University of Rome, Rome, Italy.
⁹ New York Medical College, Valhalla, NY, USA.
¹⁰ Leiden University, Leiden, the Netherlands.
¹¹ Hospital Santa Cruz, Carnaxide, Portugal.
¹² Johns Hopkins University, Baltimore, MD, USA.
¹³ East Carolina University, Greenville, NC, USA.
¹⁴ Fimlab Laboratories, Tampere, Finland.
¹⁵ Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
¹⁶ University of Alabama at Birmingham, Birmingham AL, USA.
¹⁷ Mayo Clinic, Rochester, MN, USA.
¹⁸ University of Utah, UT, USA.
¹⁹ Brigham and Women's Hospital, Boston, MA, USA.
²⁰ Papworth Hospital, Cambridgeshire, UK.
²¹ Pisa University Hospital, Pisa, Italy.
²² University of Nebraska, NE, USA.
²³ Cleveland Clinic, Cleveland, OH, USA.
²⁴ St George Medical School, University of London, London, UK.
²⁵ Sheffield Teaching Hospitals, Sheffield, UK.
²⁶ University of Amsterdam, Amsterdam, the Netherlands.
²⁷ University of Ottawa, Ottawa, Ontario, Canada.

PMID: 26051917
DOI: 10.1016/j.carpath.2015.05.001

Free article

Review

Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases

James R Stone et al. Cardiovasc Pathol. 2015 Sep-Oct.

Free article

. 2015 Sep-Oct;24(5):267-78.

doi: 10.1016/j.carpath.2015.05.001. Epub 2015 May 16.

Authors

Affiliations

¹ Massachusetts General Hospital, Boston, MA, USA. Electronic address: jrstone@partners.org.
² University Paris-Descartes, France. Electronic address: patrick.bruneval@egp.aphp.fr.
³ University of Padua Medical School, Padua, Italy.
⁴ University of Catania, Catania, Italy.
⁵ Russian Academy of Medical Sciences, Irkutsk, Russia.
⁶ University of Texas Health Science Center at Houston, Houston, TX, USA.
⁷ Toronto General Hospital, Toronto, Canada.
⁸ Sapienza, University of Rome, Rome, Italy.
⁹ New York Medical College, Valhalla, NY, USA.
¹⁰ Leiden University, Leiden, the Netherlands.
¹¹ Hospital Santa Cruz, Carnaxide, Portugal.
¹² Johns Hopkins University, Baltimore, MD, USA.
¹³ East Carolina University, Greenville, NC, USA.
¹⁴ Fimlab Laboratories, Tampere, Finland.
¹⁵ Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
¹⁶ University of Alabama at Birmingham, Birmingham AL, USA.
¹⁷ Mayo Clinic, Rochester, MN, USA.
¹⁸ University of Utah, UT, USA.
¹⁹ Brigham and Women's Hospital, Boston, MA, USA.
²⁰ Papworth Hospital, Cambridgeshire, UK.
²¹ Pisa University Hospital, Pisa, Italy.
²² University of Nebraska, NE, USA.
²³ Cleveland Clinic, Cleveland, OH, USA.
²⁴ St George Medical School, University of London, London, UK.
²⁵ Sheffield Teaching Hospitals, Sheffield, UK.
²⁶ University of Amsterdam, Amsterdam, the Netherlands.
²⁷ University of Ottawa, Ottawa, Ontario, Canada.

PMID: 26051917
DOI: 10.1016/j.carpath.2015.05.001

Abstract

Inflammatory diseases of the aorta include routine atherosclerosis, aortitis, periaortitis, and atherosclerosis with excessive inflammatory responses, such as inflammatory atherosclerotic aneurysms. The nomenclature and histologic features of these disorders are reviewed and discussed. In addition, diagnostic criteria are provided to distinguish between these disorders in surgical pathology specimens. An initial classification scheme is provided for aortitis and periaortitis based on the pattern of the inflammatory infiltrate: granulomatous/giant cell pattern, lymphoplasmacytic pattern, mixed inflammatory pattern, and the suppurative pattern. These inflammatory patterns are discussed in relation to specific systemic diseases including giant cell arteritis, Takayasu arteritis, granulomatosis with polyangiitis (Wegener's), rheumatoid arthritis, sarcoidosis, ankylosing spondylitis, Cogan syndrome, Behçet's disease, relapsing polychondritis, syphilitic aortitis, and bacterial and fungal infections.

Keywords: Aorta; Aortitis; Atherosclerosis; Inflammatory aneurysm.

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Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases

Affiliations

Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Research Materials