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Review
. 2015 Dec:141:15-22.
doi: 10.1016/j.exer.2015.06.002. Epub 2015 Jun 4.

Animal models of glucocorticoid-induced glaucoma

Darryl R Overby  1 , Abbot F Clark  2
Affiliations
Review

Animal models of glucocorticoid-induced glaucoma

Darryl R Overby et al. Exp Eye Res. 2015 Dec.

Abstract

Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.

Keywords: Glaucoma; Glucocorticoid; Intraocular pressure; Ocular hypertension; Steroid glaucoma.

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References

    1. Aihara M. Ocular Hypertension in Mice with a Targeted Type I Collagen Mutation. Invest Ophthalmol Vis Sci. 2003;44:1581–1585. - PubMed
    1. Aihara M, Lindsey JD, Weinreb RN. Aqueous humor dynamics in mice. Invest Ophthalmol Vis Sci. 2003;44:5168–5173. - PubMed
    1. Armaly MF. Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics.: I. The Effect of Dexamethasone in the Normal Eye. Arch Ophthalmol. 1963a;70:482–491. - PubMed
    1. Armaly MF. Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: II. The Effect of Dexamethasone in the Glaucomatous Eye. Arch Ophthalmol. 1963b;70:492–499. - PubMed
    1. Armaly MF. Statistical attributes of the steroid hypertensive response in the clinically normal eye. I. the demonstration of three levels of response. Invest Ophthalmol. 1965;4:187–197. - PubMed

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