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Review
. 2015 Nov;96(2):257-61.
doi: 10.1016/j.critrevonc.2015.05.013. Epub 2015 May 27.

Limited advances in therapy of glioblastoma trigger re-consideration of research policy

Guido Frosina  1
Affiliations
Review

Limited advances in therapy of glioblastoma trigger re-consideration of research policy

Guido Frosina. Crit Rev Oncol Hematol. 2015 Nov.

Abstract

Glioblastoma (GB - WHO grade IV) is the most frequent and lethal primary brain tumour with median overall survival of 7-15 months after diagnosis. As in other cancer research areas, an overwhelming amount of pre-clinical research acquisitions in the GB field have not been translated to patients' benefit, potentially due to inappropriate treatment schedules and/or trial designs in the clinical setting. The recent failure of promising anti-VEGF bevacizumab to improve GB patients' overall survival recapitulates this sense of frustration. The following measures are proposed.

Keywords: Bevacizumab; Bibliometrics; Glioma; Treatment protocol; Treatment quality.

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