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Review
. 2015 May 22:6:517.
doi: 10.3389/fmicb.2015.00517. eCollection 2015.

Broad-spectrum antiviral agents

Jun-Da Zhu  1 , Wen Meng  1 , Xiao-Jia Wang  1 , Hwa-Chain R Wang  2
Affiliations
Review

Broad-spectrum antiviral agents

Jun-Da Zhu et al. Front Microbiol. .

Abstract

Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics. This review discusses current knowledge, prospective applications, opportunities, and challenges in the development of broad-spectrum antiviral agents.

Keywords: antiviral agent; broad-spectrum; cellular defense; replication; viral entry.

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Figures

FIGURE 1
FIGURE 1
Schematic diagram of targets for broad-spectrum antiviral agents. (a) Cathepsin L (b) gP120 (c) CD4 (d) six-helix bundle (e). N-glycan terminal mannose residues (f) hemagglutinin (g) sialic acid (h) protein Z (i) TSG101 (j) viral RNA polymerase (k) DHODH l. XPO1 → activate - l block. (1) 5705213 (2) PVP-coated nano-silver (3) HP-OVA (4) CV-N 5. eCD4Ig. (6) p20 (7) Griffithsin (8) CR6261 (9) DAS181 (10) FGI-104 (11) Compound 0013 (12) VL-01 (13) Bortezomib (14) MG132 (15) JMN3-003 (16) BCX4430. (17) Compound A3 (18) Cmp1 (19) KPT-335 (20) Antimycin A (21) BEZ-235. (22) Akt-IV (23) Rapamycin (24) DRACOs (25) 5′pppRNA (26) GSK983. (27) Compounds C1 and C2.
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References

    1. Albiol Matanic V., Castilla V. (2004). Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int. J. Antimicrob. Agents 23 382–389. 10.1016/j.ijantimicag.2003.07.022 - DOI - PubMed
    1. Ashiru O., Howe J. D., Butters T. D. (2014). Nitazoxanide, an antiviral thiazolide, depletes ATP-sensitive intracellular Ca(2+) stores. Virology 462–463, 135–148. 10.1016/j.virol.2014.05.015 - DOI - PubMed
    1. Askjaer P., Jensen T. H., Nilsson J., Englmeier L., Kjems J. (1998). The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. J. Biol. Chem. 273 33414–33422. 10.1074/jbc.273.50.33414 - DOI - PubMed
    1. Barrientos L. G., Lasala F., Otero J. R., Sanchez A., Delgado R. (2004). In vitro evaluation of cyanovirin-N antiviral activity, by use of lentiviral vectors pseudotyped with filovirus envelope glycoproteins. J. Infect. Dis. 189 1440–1443. 10.1086/382658 - DOI - PubMed
    1. Barton C., Kouokam J. C., Lasnik A. B., Foreman O., Cambon A., Brock G., et al. (2014). Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. Antimicrob. Agents Chemother. 58 120–127. 10.1128/aac.01407-13 - DOI - PMC - PubMed