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Review
. 2017 Nov;27(6):1093-1097.
doi: 10.3109/14397595.2015.1059982. Epub 2015 Jul 20.

TAFRO syndrome: 2 cases and review of the literature

Mikako Kawashima  1 , Taro Usui  1 , Hideyuki Okada  1 , Ichiro Mori  1 , Masahiro Yamauchi  1 , Takahide Ikeda  1 , Kazuo Kajita  1 , Yusuke Kito  2 , Tatsuhiko Miyazaki  2 , Kei Fujioka  3 , Tatsuo Ishizuka  3 , Hiroyuki Morita  1
Affiliations
Review

TAFRO syndrome: 2 cases and review of the literature

Mikako Kawashima et al. Mod Rheumatol. 2017 Nov.

Abstract

Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome and have reviewed another eighteen previously reported cases. Histological findings of the lymph nodes and levels of interleukin 6 (IL-6) and vascular endothelial growth factor in both serum/plasma and effusions are important characteristics for diagnosing this syndrome.

Keywords: Anasarca; Fever; Organomegaly; Reticulin fibrosis; Thrombocytopenia.

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