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. 2015 Jul 1;137(25):8038-41.
doi: 10.1021/jacs.5b04940. Epub 2015 Jun 23.

A General Approach to Sequence-Controlled Polymers Using Macrocyclic Ring Opening Metathesis Polymerization

Will R Gutekunst  1 , Craig J Hawker  1   2
Affiliations

A General Approach to Sequence-Controlled Polymers Using Macrocyclic Ring Opening Metathesis Polymerization

Will R Gutekunst et al. J Am Chem Soc. .

Abstract

A new and general strategy for the synthesis of sequence-defined polymers is described that employs relay metathesis to promote the ring opening polymerization of unstrained macrocyclic structures. Central to this approach is the development of a small molecule "polymerization trigger" which when coupled with a diverse range of sequence-defined units allows for the controlled, directional synthesis of sequence controlled polymers.

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Figures

Scheme 1
Scheme 1. Development of Macrocyclic ROMP
Scheme 2
Scheme 2. Polymerization Trigger Synthesis
Scheme 3
Scheme 3. Synthesis and X-ray Crystal Structure of Macrocyclic Monomer 9
Scheme 4
Scheme 4. Degradation of P-11 with TBD
See this image and copyright information in PMC

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